ABSTRACT
Objective To explore the clinicopathologic characteristics,diagnosis and therapy of differentiated thyroid cancer in children and adolescents.Methods The files of 68 children with differentiated thyroid cancer in our hospital from 1989-2002 were retrospectively reviewed.Results All patients received operationand postoperative thyroxin therapy.Seventeen patients underwent near-total or total thyroidectomy and 51 patients underwent ipsilateral subtotal thyroidectomy.Central compartment,unilateral and bilateral cervical lymphadenectomy was performed in 24,36,and 8 patients respectively.The patients in this group were all aliveduring one year to three years follow up(4 patients were lost to followup contact after three years).Conclusions The optimal treatment of differentiated thyroid cancer in pediatric patients continues to be debated.The leading treatment is surgical.Selection of proper surgical procedure and comprehensive postoperativetherapy are important for good outcome.Endocrine therapy was given to all of the patients postoperatively.
ABSTRACT
Objective:To study the effect of Cyclosporine A preconditioning on liver preservation and transplantation in rat.Methods:Rats were divided randomly into control group (group A,HTK solution preservation) and CsA precondioning group (groupB,HTK solution preservation+1?M CsA).The livers of two groups were had been all preservated for 12 hours before operation of orthotopic liver transplantation.The content of serum AST,ALT,LDH were all assayed during preservation in 0h,12h and 7d post liver transplantation,as well as determination of mitochondrial respiration function parameters (RCR and P/O).The change of cell morphology and apoptosis were also observed by TUNEL stain,and miclroscopes in two groups.Results:The content of serum ALT,AST and LDH in group B were less than in group A after presenvation for 12 hours.RCR and P/O parameters of mitochondrial respiration in group B on preservation for 12h.and for 30 min after operation were more than in group A.Cell morphology and apoptosis changed slingtly compared with group B.Conclusion:CsA preconditioning can relieve injury of donated liver during cold preseration and reperfusion.It protects mitochondrial fuction of liver cells and inlibits cell apoptosisa.